3M Zeta Plus VR

3M™ Zeta Plus VR Series Filters

The removal and inactivation of contaminating viruses from biotherapeutics is a requisite for ensuring final product safety.
Zeta Plus VR cartridge depth filters remove significant levels of viruses from biological fluids.
They provide validatable viral titer reduction, high flow rates, scalability, economy, disposability and ease-of-use in the biological manufacturing environment.
The Zeta Plus VR Series includes specific filter media recommendations for virus removal from blood plasma proteins and bioprocess derived cell culture fluids.
Zeta Plus depth filtration offers an attractive and economical alternative to other available technologies for reduction of viral burden.
Zeta Plus VR Series depth filters can be used as a bolt-on processing step to existing in-process viral clearance methodologies, providing an added measure of end-product safety.

Features / Benefits

• Validatable viral log reduction
• Provides added level of viral safety
• Assurance of filter media consistency & performance
• Single-use, disposable design eliminates validation concerns associated with reusable clearance options (chromatography column sanitisation & regeneration)
• Eliminates concern over virus carryover from one purification cycle to the next
• Facilitates scaleup from small volume feasibility trials & validation studies to production scale operations
• Enable high flow processes
• Robust in-situ steam-sterilisable cartridges
• Drug Master Files simplify FDA submissions
• Regulatory Support Files detail filter media regulatory compliance & safety data
• Provides added level of validatable viral clearance
• Can replace or augment chromatography columns or function as prefilter to final virus removal membrane filter

Operating Conditions

• Maximum Operating Temperature 82° C (180° F
• Recommended Flow Rate 54 l//m²

Typical Applications

• Processing of human plasma-derived proteins
• Recombinant proteins from cell culture and fermentation
• Monoclonal antibodies
• Serum and other raw materials derived from animal sources