Chiral separation by enantioselective inclusion complexation-organic solvent nanofiltration

A novel enantioseparation process using the combination of EIC and OSN has been 0.60 FIRST CYCLE SECOND CYCLE 0.50 R S ee 0.40 0.30 Step B Step D Step B Step D Combined streams –20 –40 0.20 1st Cycle (%) 2nd Cycle (%) Step B –46 –34 ee of S / % R and S enantiomers in the permeate / mmol Table 1 ee and the yield of permeates 0.70 Step D ee (of R) Yield (of R) ee (of S) Yield (of S) –60 0.10 –80 0.00 –100 1B1 1B2 1B3 1D1 1D2 2B1 2B2 2B3 2D1 2D2 2D3 Filtration numbers Fig. 2. Elution profile of resolution-filtration process and ee of the permeate stream in each filtration (indicated in Fig. 1) in two cycles. Step B is the elution of R and Step D is the elution of S. Positive ee indicates S-rich permeate. Negative ee indicates R-rich permeate.