RGD immobilization on PLLA membranes to promote biocompatibility

RGDS was successfully immobilized on the PLLA scaffolds via plasma treatment. It was observed that the immobilized RGDS promoted attachment of ROS cells to PLLA. Also, more cells were found in the RGDS-modified scaffold than in the unmodified scaffold, tending to form mineralized foci. The results suggest that the immobilization of RGD makes PLLA scaffolds more suitable for culture of osteoblast-like cells and facilitates their application in bone regeneration.